Scedosporium apiospemum - the asexual form of Pseudallescheria boydii are ubiquitous saprophytic fungi that commonly cause cutaneous infections. However in certain circumstances can also cause invasive disease which can involve the central nervous system. We described the case of an 86-year-old previously healthy man that developed acute sinusitis and was treated in ENT department. Cultures of sinus drainage specimens were negative for both fungi and bacteria. Ten days later the patient presented again in the emergency department, lethargic with a right side hemiparesis. Cranial CT and brain MRI with contrast medium revealed a left parietal intracerebral ring-enhanced lesion with surrounding brain edema. After surgical drainage of the abscess a microbiological examination of the purulent material was done and a fungal species (Scedosporium apiospermum) was isolated. An antifungal therapy was initiated after these results but despite this the patient’s condition worsened more and finally he died due to multiple organ failure 20 days after his first admission.