Cyclodextrins are well known host molecules able to form inclusion complexes with a wide variety of guest molecules, including drugs (such as sulconazole nitrate - a very efficient, but also toxic antifungal drug).
Aim. To investigate the effects of the addition of α-cyclodextrin (α-CD) on the light absorption by sulconazole nitrate (SULC) in aqueous media.
Material and method. To obtain the binding constants between α-CD and SULC, the UV spectra of solutions containing the same total concentration of CD and SULC and different molar ratios between CD and SULC were analyzed. The formation of host-guest inclusion complexes was indicated by UV spectroscopy. The binding constants sulconazole to α-cyclodextrin in bidistilled water have been determined using Rose-Drago method.
Results. After calculation, we found that the stoichiometry for the inclusion complexation is 1:1, indicating a good interaction between the two components. Discussions. The α-CD-SULC inclusion complex exhibits a high value of the inclusion complex binding constants, reflecting the good stability of the obtained compound, and indicating this structure as a promising drug carrier useful in therapy.