In most cases, the antifungal molecules are not soluble in water and that fact represents a major problem in the absorption and spreading of the active substances. Further, these molecules exhibit a high toxicity toward self structures of the host organisms, both at hepatic and renal level. That’s why, the use of some carrier molecules which may eliminate these difficulties, improving concomitantly the bioavailability of antifungals in target sites and reducing the adverse reactions, is imperative. The most suitable carrier systems comprise the liposomes, nanoparticles and cyclodextrins.