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| Evaluation of the antifungal effect of a new propiconazole derivate against 64 yeast strains isolated from vaginal mycoses |  |
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MIHAI MAREŞ1, ALINA ŞTEFANACHE2, IULIANA POPOVICI2, FLIUR MACAEV3, DUMITRU BUIUC4
(1) Catedra de Microbiologie, Facultatea de Medicină Dentară, Universitatea „Petre Andrei” Iaşi,
(2) Facultatea de Farmacie, Universitatea de Medicină şi Farmacie „Gr. T. Popa” Iaşi
(3) Institutul de Chimie Organică, Chişinău, Republica Moldova
(4) Facultatea de Medicină, Universitatea de Medicină şi Farmacie „Gr. T. Popa” Iaşi
(2) Facultatea de Farmacie, Universitatea de Medicină şi Farmacie „Gr. T. Popa” Iaşi
(3) Institutul de Chimie Organică, Chişinău, Republica Moldova
(4) Facultatea de Medicină, Universitatea de Medicină şi Farmacie „Gr. T. Popa” Iaşi
Received: 14.08.2007 / Accepted: 10.09.2007
Aim.The aim of this paper is to present the evaluation of the antifungal activity of a new triazole derivative – propiconazole nitrate, under in vitro conditions resembling the vaginal microenvironment.
Material and method. We performed the susceptibility testing in a vagina-simulative medium using the CLSI M27-A2 standard guidelines and 64 clinical yeast strains. The range of tested concentrations has varied between 0.0625-16 mg/L. The minimal inhibitory concentration (MIC) was considered the lowest concentration of the drug which corresponds to 80% reduction in turbidity compared with that of the drug-free growth control.
Results. We obtained a MIC90 of 0.5 mg/L and a MIC50 of 0.0625 mg/L respectively.
Discussion. The tests exhibited a strong antifungal effect of this new azole compound which may be useful for the treatment of mycotic vaginitis. These results encourage the future researches in order to determine the interpretative breakpoints, to evaluate the in vitro – in vivo correlations, and to find the appropriate doses in order to start clinical trials.
Keywords:
propiconazole nitrate, antifungal, vaginitis