Aim. Complexation between sulconazole (SULC), an imidazole derivative with in vitro antifungal and antiyeast activity, and cyclodextrins (alpha cyclodextrin (αCD), beta cyclodextrin (βCD), gamma cyclodextrin (γCD) and hydroxypropyl beta cyclodextrin (HP βCD) was studied in aqueous solution and in solid states.

Material and method. Complexation in solution was evaluated using Higuchi-Conors phase solubility studies in the solid state X Ray diffraction studies were used. Results. Solubility studies suggested the existence of inclusion complex between SULC and αCD, βCD, γCD and HP βCD. X Ray studies confirmed the formation of the inclusion complexes.

Discussion. Solubility of SULC in solid complexes was studied by the dissolution method and it was found to be much more soluble than the uncomplexed drug.